Metaplastic squamous cell carcinoma (SCC) of the breast is a very rare form of breast malignancy accounting for less than 0.1% of all breast carcinomas. We report a case of primary SCC of the breast in a 67-year-old Asian woman. Our purpose for this review is to enable a better understanding of the disease and to find an optimal approach to therapy.Author: Veerauo V. Konkankit. Metaplastic carcinomas represent a morphologically heterogeneous group of invasive breast cancers in which a variable portion of the glandular epithelial cells comprising the tumor have undergone transformation into an alternate cell type—either a nonglandular epithelial cell type (e.g., squamous) or a mesenchymal cell type (e.g., spindle, chondroid, osseous, myoid).
Metaplastic Breast Cancer (MpBC), also called metaplastic carcinoma of the breast, is an extremely rare type of breast cancer. Currently it is not well understood,(1) with no disease specific treatment protocol. Metaplastic breast cancer describes a cancer that is a mixture of different cell types. What are the Symptoms of Metaplastic Breast Cancer? A lump or lumps in the breast or under the arm. Thickening of the skin of the breast. nipple tenderness. nipple discharge or physical changes such as nipple turned inward or a persistent sore. a change in the size or shape of the breast. Skin.
Metaplastic carcinoma of the breast is a rare but aggressive type of breast cancer that has been recognized as a unique pathologic entity by the World Health Organization. Morphologically, it is characterized by the differentiation of neoplastic epithelium into squamous cells and/or mesenchymal-looking elements (squamous. Apr 26, 2019 · Metaplastic breast cancer (metaplastic carcinoma of the breast) is a very uncommon type of breast cancer. It is a form of invasive ductal cancer, meaning that it forms in the milk ducts and then moves into other tissues of the breast. It can be aggressive and fast-growing, and relatively little is known about metaplastic breast cancer's causes or long-term prognosis.
Nov 14, 2013 · Metaplastic breast cancer (MBC) is a rare subtype of invasive breast cancer that tends to have an aggressive clinical presentation as well as a variety of distinct histologic designations. Few systemic treatment options are available for MBC, as it has consistently shown a suboptimal response to standard chemotherapy regimens.Author: Theresa L Schwartz. Nov 14, 2013 · Abstract. Metaplastic breast cancer (MBC) is a rare subtype of invasive breast cancer that tends to have an aggressive clinical presentation as well as a variety of distinct histologic designations. Few systemic treatment options are available for MBC, as it has consistently shown a suboptimal response to standard chemotherapy regimens.Cited by: 25.
Mar 29, 2017 · Frequent overexpression of programmed death-ligand 1 has recently been demonstrated in metaplastic breast cancer, which is a rare breast cancer subtype with limited treatment options.Cited by: 11. Metaplastic breast cancer Chemotherapy. Chemotherapy will be recommended for many people with metaplastic breast cancer. Radiotherapy. If you have breast-conserving surgery you will usually be offered radiotherapy to Hormone (endocrine) therapy. The hormone oestrogen can stimulate some breast.